Molecular crosstalks inLeishmania-sandfly-host relationships

Molecular analysis of commensal host-microbial relationships in the intestine.

Human beings contain complex societies of indigenous microbes, yet little is known about how resident bacteria shape our physiology. We colonized germ-free mice with Bacteroides thetaiotaomicron, a prominent component of the normal mouse and human intestinal microflora. Global intestinal transcriptional responses to colonization were observed with DNA microarrays, and the cellular origins of se...

Autophagy and Autoimmunity Crosstalks

Autophagy, initially viewed as a conserved bulk-degradation mechanism, has emerged as a central player in a multitude of immune functions. Autophagy is important in host defense against intracellular and extracellular pathogens, metabolic syndromes, immune cell homeostasis, antigen processing and presentation, and maintenance of tolerance. The observation that the above processes are implicated...

Sandfly Fever

Sik,?My thanks are due to Lieutenant Stott and Major Rogers for their criticisms of my paper published in the " Gazette " for August last. Since its publication, Lieutenant-Colonel Birt, K. A.M.C., has very kindly sent me reprints of his recent articles in the Journal of the R. A. M. C. on " Phlebotomus Fever in Malta and Crete" and " Sandfly Fever in India." His clinical description of the fev...

Sandfly Fever

Comparative aspects of host-parasite and host-tumor relationships.